Head of ADME/DMPK - Mechelen, BE

Pleased to meet you, we are Galapagos, a dynamic growing Biotech company with offices across Europe and in US, headquartered in Mechelen, Belgium.

We are in the business of changing lives. Focusing on high unmet medical needs, we synergize compelling science, technology, and collaborative approaches to create a deep pipeline of best-in-class small molecules, CAR-T therapies and biologics in oncology and immunology. With capabilities from lab to patient, including Decentralized Manufacturing Unit(s) of CAR-T, we are committed to challenging the status quo and delivering results for our patients, employees and shareholders.

We pioneer for patients. We need thought leaders and rapid thinkers, entrepreneurs in spirit and status quo-fighters. Collaborative innovators and perseverant idealists. We need the best-in-class. In other words, we need you : The ‘make-it-happener’.

We are expanding our US footprint to set-up our decentralized CAR-T network and further build our research capabilities in the US.

We are currently looking for a Head of ADME/DMPK - Mechelen, BE

Scope of the role

You will lead and manage the DMPK department and ensure that support the small molecule and antibody drug discovery projects with ADME/PK data all the way to human PK predictions. You will also contribute to the transition of new drug candidates from discovery to development and throughout development to MAA/NDA. You are responsible for the design of the scientific and organizational strategy, focused on DMPK/ADME, to develop novel competitive therapeutic drugs. You will lead the implementation of this strategy within your own team. As a leader of the ADME/DMPK Team, you will ensure teamwork with a special emphasis on high quality of data delivered in the best timelines. The communication between the DMPK/ADME department and other Discovery and Development teams should be handled with professionalism.

Your role

• Design the scientific strategy for the DMPK/ADME department,
• Implement this strategy in the small molecule and antibody research projects
• Prioritize and allocate resources to progress Galapagos extended drug discovery portfolio
• Act as a DMPK/ADME expert and mentor
• Be accountable for scientific strategy, budget and resources
• Bring new approaches and technologies to provide state of the art support to Galapagos portfolio
• Lead, manage and coordinate scientific teams appointed to its department, by motivating and empowering the team members
• In addition to your role in coordinating the team, you will also take on the management of 2-3 projects individually.

Who are you?

• PhD in life sciences with proven track record in ADME/DMPK for at least 15 years in the pharmaceutical industry supporting drug discovery and development projects.
• Experienced manager
• In-depth expertise in ADME/DMPK and PK/PD relationships
• Experience with drug delivery and disposal through various routes of administration
• Experience with modalities other than small molecules would be welcome, especially in the field of antibodies
• Knowledge with essential software and able to establish human PK predictions
• In depth knowledge in PBPK and PK/PD analysis and simulation

What’s in it for you?
You will be part of a fast growing and amazing company with a rejuvenated preclinical pipeline. As ‘make-it-happener’ you will get all the support you need to make your job successful. At Galapagos we aim to recruit the best people, who stand out among their peers, with integrity and excellent interpersonal and organizational skills. Our employees are the strength behind Galapagos, a highly motivated team, eager to maintain Galapagos’ leading position and achieve breakthroughs in pharmaceutical research. Galapagos offers a competitive remuneration package and a dynamic work environment.

We are Galapagos: together we can make it happen...!